Researchers complete large-scale validation of biomarker for diagnosis of IBS-D

Researchers have completed the first large-scale validation of anti-cytolethal distending toxin B and anti-vinculin antibodies as a mechanism-based biomarker for diarrhea-predominant irritable bowel syndrome, according to data released in advance of Digestive Disease Week. “Basically, for the first time, we have a biomarker that can help to make an accurate diagnosis of IBS,” Mark Pimentel, MD, from Cedars-Sinai Medical Center in Los Angeles, told Healio Gastroenterology. “The biomarker is based on a cause of IBS, food poisoning that leads to autoimmunity.”