Patients with dermatomyositis and polymyositis had higher levels of osteopontin in skeletal muscles and serum than control participants, according to researchers’ findings.Forty-five patients with either dermatomyositis or polymyositis (DM / PM) who were admitted to the First Affiliated Hospital of Chonqing Medical University between July 2010 and June 2014 and diagnosed according to Bohan and Peter criteria were studied. Twenty-seven of the patients were diagnosed with PM, and 18 had a diagnosis of DM. Forty-five participants matched for age and gender were also included, in addition to 10 patients (four men and six women, ages 14 years to 60 years) who had normal serum creatinine kinase (CK), muscle histology, histochemistry, immunohistology and ultrastructural morphology but were suspected to have a neuromuscular disease.
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