Patients with rheumatoid arthritis and lower BMI showed a better response to treatment with infliximab compared with patients with a higher BMI, according to study findings.Researchers conducted a single-center, retrospective study of 76 patients with rheumatoid arthritis (RA) treated with infliximab between January 2005 and January 2012 at Bichat Hospital in Paris. Patients had a mean age 49.1 years and a mean disease duration of 8 years, and 63% of the patients were women. Mean disease activity score in 28 joints (DAS28) was 5.6. Twenty-five patients had a BMI less than 25 kg/m2, 29 had a BMI of 25 kg/m2 to 30 kg/m2 and 22 had a BMI of greater than 30 kg/m2; median BMI was 26.6 kg/m2. Although clinical rheumatoid arthritis (RA) covariates were similar among the three groups, fewer overweight patients had previously been treated with tumor necrosis factor-alpha (TNF-a) inhibitor.
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